POLR3A variants with striatal involvement and extrapyramidal movement disorder
نویسندگان
چکیده
منابع مشابه
Relating Spontaneously Reported Extrapyramidal Adverse Events to Movement Disorder Rating Scales
BACKGROUND While antipsychotic-induced extrapyramidal symptoms (EPS) and akathisia remain important concerns in the treatment of patients with schizophrenia, the relationship between movement disorder rating scales and spontaneously reported EPS-related adverse events (EPS-AEs) remains unexplored. METHODS Data from four randomized, placebo- and haloperidol-controlled ziprasidone trials were a...
متن کاملNeuroleptic-induced movement disorders: deconstructing extrapyramidal symptoms.
The neurological risks and benefits of atypical neuroleptics have received considerable attention in the medical literature, but there have been few controlled studies examining these risks in elderly patients. Well-designed, longterm prospective studies are needed to identify the safest and most effective treatment regimens for elderly patients, but until these studies are complete, clinicians...
متن کاملInvolvement of ventrolateral striatal dopamine in movement initiation and execution: a microdialysis and behavioral investigation.
Previous studies have demonstrated that the ventrolateral region of the rat neostriatum is the site at which dopamine depletions produce profound motor deficits that interfere with food handling and lever pressing. In the present work, two experiments were undertaken to investigate the role of ventrolateral striatal dopamine in lever pressing. The first experiment was a detailed characterizatio...
متن کاملExtrapyramidal involvement in amyotrophic lateral sclerosis: backward falls and retropulsion.
Three patients with sporadic amyotrophic lateral sclerosis (ALS) presented with a history of backward falls. Impaired postural reflexes and retropulsion accompanied clinical features of ALS. Hypokinesia, decreased arm swing, and a positive glabellar tap were noted in two of these three patients. Cognitive impairment, tremor, axial rigidity, sphincter dysfunction, nuchal dystonia, dysautonomia, ...
متن کاملGenetic Variants in Diseases of the Extrapyramidal System
Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular genetic studies, leading to the detection of genetic mutations and loci, has co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: neurogenetics
سال: 2020
ISSN: 1364-6745,1364-6753
DOI: 10.1007/s10048-019-00602-4